The M3 (Malignome, Metabolome, Microbiome) Research Center affiliated with University of Tübingen and the German Cancer Research Center (DKFZ). Our laboratory “Chronic Inflammation and Cancer” led by the director of the M3 Research Institute (Tübingen) has a long-standing interest in studying pathways involved in chronic inflammation and metabolic dysregulation in cancer and inflammatory diseases, specifically MASLD dysfunction metabolism associated liver disease but also smoking induced lung cancer as well as organ cross talk in the context of hepatitis and skin desease. For example, we have contributed in the understanding of the role of adaptive and innate immunity in fatty liver disease and subsequent liver cancer (Haybeck et al., 2009 Cancer Cell, Malehmir et al, Nature Medicine 2019, Wolf et al. Cancer Cell 2014, Gallage et al., Cell Metabolism 2024) as well as demonstrated that liver cancer induced by MASLD is resistant to immunotherapy (Pfister et al. Nature 2021; Li et al., Nature 2026). We have also contributed to the understanding of the role of DNA damage pathways in liver cancer (Boege et al. Cancer Cell 2017), how chronic mitochondrial dysfunction and ROS results in cholangiocellular carcinoma (Yuan et al. Cancer Cell 2017) and how chronic inflammatory pathways drive age-related gliosis (O’Connor et al. Cancer Cell 2019).

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M3 Research Center

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